Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ighmtm1Che
Name:	immunoglobulin heavy constant mu; targeted mutation 1, Jianzhu Chen
MGI ID:	MGI:1934014
Synonyms:	muS-, secreted IgM-, sIgM-, Smu-
Gene:	Ighm  Location: Chr12:113382446-113386350 bp, - strand  Genetic Position: Chr12, 62.1 cM, cytoband F1-2
Alliance:	Ighmtm1Che page

Germline Transmission:	Earliest citation of germline transmission: J:47425
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was constructed in which the exon encoding the secreted form of the immunoglobulin mu (IgM) heavy chain and its three downstream poly(A) sites were replaced by a cDNA fragment encoding the constant region mu4 exon and the exon encoding the membrane-bound form of IgM. The resultant homozygous mutant mice had B cells that did not secrete IgM, but did express membrane-bound IgM. (J:47425)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ighm Mutation:	55 strains or lines available

Original:	J:47425 Boes M, et al., Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM. J Immunol. 1998 May 15;160(10):4776-87
All:	54 reference(s)