Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cattm1Ysh
Name:	catalase; targeted mutation 1, Ye-Shih Ho
MGI ID:	MGI:3051232
Synonyms:	Cat-, catalase-
Gene:	Cat  Location: Chr2:103284249-103315498 bp, - strand  Genetic Position: Chr2, 54.43 cM
Alliance:	Cattm1Ysh page

Germline Transmission:	Earliest citation of germline transmission: J:91752
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of intron 4 and exon 5 were replaced by a neo cassette. Southern blot confirmed recombination. A 50-70% decrease in mRNA was found in heterozygotes and no mRNA was found in homozygotes by Northern blot analysis. Western blot indicated absence of protein in mutant tissue samples. (J:91752)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cat Mutation:	30 strains or lines available

Original:	J:91752 Ho YS, et al., Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury. J Biol Chem. 2004 Jul 30;279(31):32804-12
All:	9 reference(s)