Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mettm2Cbm
Name:	met proto-oncogene; targeted mutation 2, Carmen Birchmeier
MGI ID:	MGI:3050810
Synonyms:	Metflox
Gene:	Met  Location: Chr6:17463799-17573979 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Alliance:	Mettm2Cbm page

Germline Transmission:	Earliest citation of germline transmission: J:91484
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 15 and a loxP-flanked neomycin selection cassette was in serted into intron 15. Transient Cre expression in ES cells excised the selection cassette from intron 15, leaving exon 15 surrounded by loxP sites. Recombination was verified by Southern blot. (J:91484)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Met Mutation:	82 strains or lines available

Original:	J:91484 Borowiak M, et al., Met provides essential signals for liver regeneration. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10608-13
All:	7 reference(s)