Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nr3c1tm2Gsc
Name:	nuclear receptor subfamily 3, group C, member 1; targeted mutation 2, Gunther Schutz
MGI ID:	MGI:1931327
Synonyms:	GR-, GRflox, Grl1loxP, Grl1tm2Gsc, GRlox, GRloxP
Gene:	Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Alliance:	Nr3c1tm2Gsc page

Germline Transmission:	Earliest citation of germline transmission: J:57315
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Insertion of loxP sites flanking exon 3. A loxP flanked neomycin/thymidine kinase cassette in intron 3 was removed by transient expression of Cre recombinase in ES cells prior to blastocyst injection. (J:57315)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:	34 strains or lines available

Original:	J:57315 Tronche F, et al., Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet. 1999 Sep;23(1):99-103
All:	123 reference(s)