Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxd10tm1Emca
Name:	homeobox D10; targeted mutation 1, Ellen M Carpenter
MGI ID:	MGI:1927871
Gene:	Hoxd10  Location: Chr2:74522268-74525449 bp, + strand  Genetic Position: Chr2, 44.13 cM
Alliance:	Hoxd10tm1Emca page

Germline Transmission:	Earliest citation of germline transmission: J:59070
Parent Cell Line:	CC1.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutation:    Insertion   Mutation details: An EcoRI linker was inserted into exon 2. This insertion is predicted to cause a frameshift altering the identity of downstream amino acids and introducing a premature stop codon 19 amino acids after the insertion. (J:59070) Inheritance:    Not Specified

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd10 Mutation:	15 strains or lines available

Original:	J:59070 de la Cruz CC, et al., Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. Dev Biol. 1999 Dec 15;216(2):595-610
All:	2 reference(s)