Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Bub1btm1Jvd
Name:	BUB1B, mitotic checkpoint serine/threonine kinase; targeted mutation 1, Jan M A van Deursen
MGI ID:	MGI:3046580
Synonyms:	Bub1bH, BubR1H
Gene:	Bub1b  Location: Chr2:118428692-118472072 bp, + strand  Genetic Position: Chr2, 59.4 cM
Alliance:	Bub1btm1Jvd page

Germline Transmission:	Earliest citation of germline transmission: J:91128
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: A loxP site, neo cassette, and cryptic exon were inserted between exons 5 and 6 and a second loxP site inserted 5' of exon 5 via homologous recombination. Western blot analysis confirmed decreased protein expression from this hypomorphic allele. (J:91128)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

List all tumor models in MMHCdb carrying Bub1btm1Jvd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bub1b Mutation:	58 strains or lines available

Original:	J:91128 Baker DJ, et al., BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet. 2004 Jul;36(7):744-9
All:	23 reference(s)