Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrp5tm1Jfh
Name:	low density lipoprotein receptor-related protein 5; targeted mutation 1, J Fred Hess
MGI ID:	MGI:3046356
Synonyms:	Lrp5-, Lrptm1Hes
Gene:	Lrp5  Location: Chr19:3634828-3736564 bp, - strand  Genetic Position: Chr19, 3.33 cM, cytoband B
Alliance:	Lrp5tm1Jfh page

Germline Transmission:	Earliest citation of germline transmission: J:91055
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding portion of exon 1 (197 bp) was replaced with an IRES-beta galactosidase reporter and an MC1-neomycin selection cassette. Absence of transcripts was confirmed by Northern blot analysis. (J:91055)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp5 Mutation:	81 strains or lines available

Original:	J:91055 Kelly OG, et al., The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development. 2004 Jun;131(12):2803-15
All:	1 reference(s)