Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Nkx3-1tm1.1Saa
Name:	NK3 homeobox 1; targeted mutation 1.1, Sarki A Abdulkadir
MGI ID:	MGI:3045877
Synonyms:	Nkx3.1-
Gene:	Nkx3-1  Location: Chr14:69428141-69432107 bp, + strand  Genetic Position: Chr14, 36.02 cM
Alliance:	Nkx3-1tm1.1Saa page

Germline Transmission:	Earliest citation of germline transmission: J:74350
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: As a result of crossing Nkx3-1tm1Saa with transgenic mice expressing cre in the germ line, the floxed exon 2 and neo cassette were excised, leaving exon 1 and a single loxP site. RT-PCR analysis and immunohistochemical analyses confirmed loss of mRNA and protein expression in the posterior prostates of mutant mice. (J:74350)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Nkx3-1tm1.1Saa

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx3-1 Mutation:	39 strains or lines available

Original:	J:74350 Abdulkadir SA, et al., Conditional loss of nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol. 2002 Mar;22(5):1495-503
All:	7 reference(s)