Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Kittm3Bsm
Name:	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 3, Peter Besmer
MGI ID:	MGI:3044952
Gene:	Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance:	Kittm3Bsm page

Germline Transmission:	Earliest citation of germline transmission: J:90485
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted Mutation:    Nucleotide substitutions   Mutation details: Using a knock-in strategy, tyrosine 567 was changed to phenylalanine in exon 11. A floxed neo was inserted into intron 9. Southern blot of mutant tails confirmed recombination. (J:90485)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:	179 strains or lines available

Original:	J:90485 Agosti V, et al., Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development. J Exp Med. 2004 Mar 15;199(6):867-78
All:	1 reference(s)