Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Nr4a3tm1Wnt Name: nuclear receptor subfamily 4, group A, member 3; targeted mutation 1, Astar Winoto MGI ID: MGI:3043761 Synonyms: Nor-1 - Gene: Nr4a3  Location: Chr4:48045153-48086447 bp, + strand  Genetic Position: Chr4, 26.07 cM, cytoband B2 Alliance: Nr4a3tm1Wnt page

Abnormal mesoderm accumulation in E7 Nr4a3tm1Wnt/Nr4a3tm1Wnt embryos Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:89944
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 3 containing the transcriptional activation domain and part of the DNA binding domain was replaced with a neo cassette via homologous recombination. In situ hybridization confirmed the absence of RNA expression in homozygous embryos. (J:89944)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

16 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr4a3 Mutation:	53 strains or lines available

Original:	J:89944 DeYoung RA, et al., The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis. J Biol Chem. 2003 Nov 21;278(47):47104-9
All:	2 reference(s)