Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm7(OTX1)Asim
Name:	orthodenticle homeobox 2; targeted mutation 7, Antonio Simeone
MGI ID:	MGI:3042842
Synonyms:	hOtx12FL
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm7(OTX1)Asim page

Germline Transmission:	Earliest citation of germline transmission: J:89361
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) Mutation:    Insertion   Mutation details: A human OTX1 cDNA flanked by the Otx2 5' and 3' UTR's replaced all the coding sequence and introns. Only 50 bp of poladenylation signal is duplicated in this allele. This allele expresses the human OTX1 protein under Otx2 transcriptional control. (J:89361)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:89361 Acampora D, et al., OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm. Gene Expr Patterns. 2003 Aug;3(4):497-501
All:	1 reference(s)