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Neu1c
Allele Detail
Summary
Symbol: Neu1c
Name: neuraminidase 1; c variant
MGI ID: MGI:3042797
Gene: Neu1  Location: Chr17:35150229-35154929 bp, + strand  Genetic Position: Chr17, 18.48 cM
Alliance: Neu1c page
Mutation
origin
Strain of Origin:  Not Applicable
Mutation
description
Allele Type:    Not Applicable
Mutation:    Nucleotide substitutions
 
Mutation detailsSequencing of the a allele revealed 4 nucleotide differences compared to the b allele. These changes alter the amino acid residues 11, 15, 17 and 19 of the encoded protein from Gly, Tyr, Ala and Arg to Arg, Cys, Val and Cys, respectively. This encoded protein has 2 fold greater activity than the protein encoded by the b allele as demonstrated in an in vitro assay. (J:49430)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neu1 Mutation:  26 strains or lines available
References
Original:  J:6860 Chorney M, et al., Monoclonal antibody to an alloantigenic determinant on beta2-microglobulin (beta 2M) of the mouse. Immunogenetics. 1982;16(1):91-3
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory