Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fkbp8tm1Tili
Name:	FK506 binding protein 8; targeted mutation 1, Tiansen Li
MGI ID:	MGI:3042750
Synonyms:	Fkbp8-
Gene:	Fkbp8  Location: Chr8:70980374-70987978 bp, + strand  Genetic Position: Chr8, 34.15 cM, cytoband C1
Alliance:	Fkbp8tm1Tili page

Germline Transmission:	Earliest citation of germline transmission: J:89364
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 through 6 were deleted and replaced with a neo cassette via homologous recombination. RT-PCR and immunoblot analysis confirmed the absence of RNA and protein expression in homozygotes. (J:89364)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp8 Mutation:	22 strains or lines available

Original:	J:89364 Bulgakov OV, et al., FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development. 2004 May;131(9):2149-59
All:	3 reference(s)