Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcne1tm1Rdn
Name:	potassium voltage-gated channel, Isk-related subfamily, member 1; targeted mutation 1, Dan M Roden
MGI ID:	MGI:3040614
Synonyms:	minK-, minK-lacZ
Gene:	Kcne1  Location: Chr16:92142889-92156356 bp, - strand  Genetic Position: Chr16, 53.57 cM
Alliance:	Kcne1tm1Rdn page

Germline Transmission:	Earliest citation of germline transmission: J:53735
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region, contained in exon 2, was replaced with an NLS-lacZ-pA PGK-neo cassette. Absence of mRNA was confirmed in mutant animals in an RNAse protection assay, and beta-galactosidase was detected in restricted areas of hearts of mutant mice. (J:53735)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

68 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Kcne1 Mutation:	13 strains or lines available

Original:	J:53735 Kupershmidt S, et al., Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res. 1999 Feb 5;84(2):146-52
All:	9 reference(s)