Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nkx2-5tm2Siz
Name:	NK2 homeobox 5; targeted mutation 2, Seigo Izumo
MGI ID:	MGI:3040604
Synonyms:	Nkx2-5neo
Gene:	Nkx2-5  Location: Chr17:27057638-27063962 bp, - strand  Genetic Position: Chr17, 13.6 cM
Alliance:	Nkx2-5tm2Siz page

Germline Transmission:	Earliest citation of germline transmission: J:89216
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted into intron 1 and an additional loxP site was inserted 3' of exon 2. Northern blot indicated a 50% reduction of mRNA in mutant adult ventricular myocardium. (J:89216)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:	21 strains or lines available

Original:	J:89216 Jay PY, et al., Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest. 2004 Apr;113(8):1130-7
All:	2 reference(s)