Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Epha2tm1Jrui
Name:	Eph receptor A2; targeted mutation 1, Joseph C Ruiz
MGI ID:	MGI:3040415
Synonyms:	Epha2-, Epha2tm1Jinc
Gene:	Epha2  Location: Chr4:141028551-141056695 bp, + strand  Genetic Position: Chr4, 73.67 cM, cytoband D-E
Alliance:	Epha2tm1Jrui page

Germline Transmission:	Earliest citation of germline transmission: J:89275
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neo cassette was inserted at nucleotide 1372, within the sequence encoding the extracellular domain. Although the resultant transcript putatively encodes a nonfunctional protein truncated at amino acid 426, no protein was detected by Western blot analysis of murine pulmonary microvascular endothelial cells from mutant mice. (J:89275)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Epha2 Mutation:	96 strains or lines available

Original:	J:89275 Brantley-Sieders DM, et al., EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci. 2004 Apr 15;117(Pt 10):2037-49
All:	27 reference(s)