Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcf7tm2Cle
Name:	transcription factor 7, T cell specific; targeted mutation 2, Hans Clevers
MGI ID:	MGI:1926299
Synonyms:	TcfdeltaV
Gene:	Tcf7  Location: Chr11:52143198-52174158 bp, - strand  Genetic Position: Chr11, 31.86 cM
Alliance:	Tcf7tm2Cle page

Germline Transmission:	Earliest citation of germline transmission: J:23255
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Hypomorph) Mutations:    Insertion, Intragenic deletion   Mutation details: A 350-bp fragment encoding part of intron IV and exon V was replaced with a neomycin cassette. A novel mRNA was detected in homozgyote thymocytes at 15% of the wild-type mRNA level. This mutant mRNA contains a splice variant of exon 4 to exon 6. This allele is considered a hypomorph. (J:23255)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7 Mutation:	24 strains or lines available

Original:	J:23255 Verbeek S, et al., An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature. 1995 Mar 2;374(6517):70-4
All:	4 reference(s)