Prm1<tm1Eddy> Targeted Allele Detail MGI Mouse (MGI:3039794)

Prm1^tm1Eddy
Targeted Allele Detail

Summary

Symbol:	Prm1^tm1Eddy
Name:	protamine 1; targeted mutation 1, Edward M Eddy
MGI ID:	MGI:3039794
Gene:	Prm1 Location: Chr16:10614196-10614687 bp, - strand Genetic Position: Chr16, 5.87 cM, cytoband cen-C3
Alliance:	Prm1^tm1Eddy page

Mutation
origin

Mouse Generated:	Earliest citation of chimera generation: J:69127
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neo cassette replaced 34 bp in exon 1 via homologous recombination. Analysis of 129 derived sperm from chimeras showed reduced protein expression. (J:69127)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Prm1 Mutation:	6 strains or lines available

Notes

ES cell line was either R1 or BK4. Haploinsufficiency of Prm1 prevents genetic transmission of the mutated allele and generation of non-chimeric heterozygous mice. All phenotype data reported are from chimeric mice.

References

Original:	J:69127 Cho C, et al., Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Nat Genet. 2001 May;28(1):82-6
All:	1 reference(s)

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