Ms4a1tm1Tft
Targeted Allele Detail
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| Symbol: |
Ms4a1tm1Tft |
| Name: |
membrane-spanning 4-domains, subfamily A, member 1; targeted mutation 1, Thomas F Tedder |
| MGI ID: |
MGI:3038963 |
| Synonyms: |
CD20- |
| Gene: |
Ms4a1 Location: Chr19:11227043-11243513 bp, - strand Genetic Position: Chr19, 8.19 cM, cytoband B
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| Alliance: |
Ms4a1tm1Tft page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:88933
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Part of exon 6 and all of exons 7-8 were replaced with a neomycin resistance gene via homologous recombination. These exons encode part of the second extracellular loop, the fourth transmembrane domain and the large C-terminal cytoplasmic domain of the endogenous protein. The resulting protein was truncated at amino acid 157 and was fused with an 88-amino-acid peptide coded for by the neo gene promoter sequence. Absence of cell-surface protein expression was verified by flow cytometry.
(J:88933)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ms4a1 Mutation: |
23 strains or lines available
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| Original: |
J:88933 Uchida J, et al., Mouse CD20 expression and function. Int Immunol. 2004 Jan;16(1):119-29 |
| All: |
5 reference(s) |
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Analysis Tools
