Gata1tm1Mym
Targeted Allele Detail
|
Symbol: |
Gata1tm1Mym |
Name: |
GATA binding protein 1; targeted mutation 1, Masayuki Yamamoto |
MGI ID: |
MGI:3038080 |
Synonyms: |
GATA-1.05, GATA1.05, GataG1.05 |
Gene: |
Gata1 Location: ChrX:7825504-7842844 bp, - strand Genetic Position: ChrX, 3.59 cM, cytoband A2
|
Alliance: |
Gata1tm1Mym page
|
|
Variable phenotypes of Gata1tm1Mym/Gata1+ female embryos including anemia and reduced number of hematopoietic cells
Show the 3 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:40321
|
Parent Cell Line: |
E14 (ES Cell)
|
Strain of Origin: |
129P2/OlaHsd
|
|
Allele Type: |
|
Targeted |
Mutation: |
|
Insertion
|
|
|
Mutation details: In order to weaken activity of the erythroid-specific promoter, homologous recombination was used to insert a neo cassette into the intergenic region between a GATA motif known to positively regulate transcription and the first erythroid specific exon (IE). The GATA is located approximately 620 bp 5' to IE. RT-PCR showed that gene expression in mutant male embryos was less than 5% of the level of expression in wild-type embryos.
(J:40321)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Gata1 Mutation: |
44 strains or lines available
|
|
Original: |
J:40321 Takahashi S, et al., Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene. J Biol Chem. 1997 May 9;272(19):12611-5 |
All: |
17 reference(s) |
|