Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	EgfrVel
Name:	epidermal growth factor receptor; velvet
MGI ID:	MGI:3037902
Synonyms:	EgfrM1Btlr
Gene:	Egfr  Location: Chr11:16702203-16868158 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
Alliance:	EgfrVel page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) (Not Applicable) Mutation:    Single point mutation   Mutation details: An A to G transition in the coding region causes the replacement of aspartic acid by glycine at position 833 (D833G). The mutation causes an alteration in the cytoplasmic tyrosine kinase domain structure and falls within a DFG motif known to be important for ATP coordination. (J:88776) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:	85 strains or lines available

Original:	J:88776 Du X, et al., Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics. 2004 Jan;166(1):331-40
All:	9 reference(s)