Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc40a1Pcm
Name:	solute carrier family 40 (iron-regulated transporter), member 1; polycythaemia
MGI ID:	MGI:1889622
Gene:	Slc40a1  Location: Chr1:45947228-45965683 bp, - strand  Genetic Position: Chr1, 23.96 cM, cytoband B
Alliance:	Slc40a1Pcm page

Strain of Origin:

(C3H/HeH x 101/H)F1

Allele Type:    Radiation induced Mutation:    Intragenic deletion   Mutation details: A 58 bp microdeletion in the Fpn1 promoter region alters transcription start sites and eliminates the iron responsive element (IRE) in the 5' untranslated region, resulting in increased duodenal and hepatic Fpn1 protein levels during early postnatal development. (J:89185, J:110585) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slc40a1 Mutation:	53 strains or lines available

Original:	J:30568 Cattanach BM, A new at mutation/ A dominant polycythaemia. Mouse Genome. 1995;93(4):1026-1029
All:	5 reference(s)