Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Adartm1Knk Name: adenosine deaminase, RNA-specific; targeted mutation 1, Kazuko Nishikura MGI ID: MGI:3032439 Synonyms: ADAR1flox Gene: Adar  Location: Chr3:89622329-89660753 bp, + strand  Genetic Position: Chr3, 39.19 cM, cytoband F2 Alliance: Adartm1Knk page

Increased apoptosis in liver of Adartm1Knk/Adartm1Knk Speer6-ps1Tg(Alb-cre)21Mgn/0 mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:87714
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Sequence encompassing exons 12 through 15 was flanked by single loxP sites in intron 11 and downstream of exon 15. (J:87714)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	124 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adar Mutation:	71 strains or lines available

Original:	J:87714 Wang Q, et al., Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem. 2004 Feb 6;279(6):4952-61
All:	13 reference(s)