Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Gt(ROSA)26Sortm1Sho
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Stuart Orkin
MGI ID:	MGI:1861931
Synonyms:	gtROSA, R26-beta-galfl-STOP, R26fslz, R26R, R26Rosa-lox-Stop-lox-LacZ, R26RstoplacZ, Rosa26fsLz, ROSA26-loxP-stoploxP-beta-geo, ROSA26R-LacZ reporter, ROSA26-stop-lacZ
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1Sho page

Germline Transmission:	Earliest citation of germline transmission: J:64291
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Conditional ready, Reporter) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert floxed (flanked by loxP) phosphoglycerate kinase-1-cytosine deaminase/phosphoglycerate kinase-1-puromycin (PGK-CD/PGK-Puro) and stop sequences between the splicing acceptor (SA) and the beta-gal-neomycin phosphotransferase fusion gene (beta-geo) sequences of the proviral ROSA 26 locus. Correctly targeted, this resulted in ES cells that were Puro resistant but G418 susceptible, and did not express beta-gal. (J:64291) Inheritance:    Not Specified

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1Sho

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:64291 Mao X, et al., Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5037-42
All:	102 reference(s)