Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gcktm1Efr
Name:	glucokinase; targeted mutation 1, Shimon Efrat
MGI ID:	MGI:1861929
Synonyms:	GK-
Gene:	Gck  Location: Chr11:5850820-5900081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Alliance:	Gcktm1Efr page

Germline Transmission:	Earliest citation of germline transmission: J:28756
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A fragment of the gene spanning exon 2 was replaced by a neomycin resistance cassette, resulting in a deletion and a frame shift of the transcript. Mice heterozygous for the targeted mutation had a 37% reduction in glucose phosphorylation activity in islet homogenates and a 28% reduction of activity in liver compared with wild-type littermates. (J:28756)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:	59 strains or lines available

Original:	J:28756 Bali D, et al., Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem. 1995 Sep 15;270(37):21464-7
All:	2 reference(s)