Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Avpr1btm1Gzt
Name:	arginine vasopressin receptor 1B; targeted mutation 1, Gozoh Tsujimoto
MGI ID:	MGI:3029988
Synonyms:	V1bR-, V1bR KO
Gene:	Avpr1b  Location: Chr1:131526977-131539738 bp, + strand  Genetic Position: Chr1, 57.09 cM, cytoband E4
Alliance:	Avpr1btm1Gzt page

Germline Transmission:	Earliest citation of germline transmission: J:87707
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3.5-kb region including the first exon and part of the first intron of the gene was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:87707)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Avpr1b Mutation:	33 strains or lines available

Original:	J:87707 Tanoue A, et al., The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions. J Clin Invest. 2004 Jan;113(2):302-9
All:	12 reference(s)