Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adartm2Phs
Name:	adenosine deaminase, RNA-specific; targeted mutation 2, Peter H Seeburg
MGI ID:	MGI:3029862
Synonyms:	adar1-, adar1Delta2-13
Gene:	Adar  Location: Chr3:89622329-89660753 bp, + strand  Genetic Position: Chr3, 39.19 cM, cytoband F2
Alliance:	Adartm2Phs page

Germline Transmission:	Earliest citation of germline transmission: J:87715
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment encompassing exons 2 through 13 was replaced with a neo cassette inserted by homologous recombination. The deleted region encodes residues 11 through 1054, which encompass the all three dsRNA-binding domains, two putative Z-DNA-binding domains, and the majority of the catalytic domain. (J:87715)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	36 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adar Mutation:	71 strains or lines available

Original:	J:87715 Hartner JC, et al., Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1. J Biol Chem. 2004 Feb 6;279(6):4894-902
All:	6 reference(s)