Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Blmhtm1Geh Name: bleomycin hydrolase; targeted mutation 1, Gregg E Homanics MGI ID: MGI:1861798 Synonyms: Bh-, Blmhtm2Geh Gene: Blmh  Location: Chr11:76836482-76878215 bp, + strand  Genetic Position: Chr11, 46.16 cM Alliance: Blmhtm1Geh page

Gross appearance and histopathology of tail dermatitis on Blmhtm1Geh/Blmhtm1Geh mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:54585
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exon 3 and flanking DNA was replaced with a neomycin selection cassette. The deleted sequences include the region encoding the catalytic cysteine of the protein. Northern blot analysis on total embryonic RNA derived from homozygous mice demonstrated that no transcript was produced from this allele. Western blot and enzymatic activity assays confirmed that no functional protein was made in homozygous mice. (J:54585)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blmh Mutation:	22 strains or lines available

Original:	J:54585 Schwartz DR, et al., The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4680-5
All:	4 reference(s)