Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dhcr24tm1Lex
Name:	24-dehydrocholesterol reductase; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:3027024
Synonyms:	Dhcr24-, DHCR24-, Dhcr24tm1Fein
Gene:	Dhcr24  Location: Chr4:106418279-106446310 bp, + strand  Genetic Position: Chr4, 49.67 cM, cytoband C7
Alliance:	Dhcr24tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:87402
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: The endogenous locus was disrupted by the insertion of a cassette containing lacZ and neo. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from brain and skin tissue. (J:87402)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dhcr24 Mutation:	33 strains or lines available

Original:	J:87402 Wechsler A, et al., Generation of viable cholesterol-free mice. Science. 2003 Dec 19;302(5653):2087
All:	10 reference(s)