Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Cav3tm1Ncnp
Name:	caveolin 3; targeted mutation 1, Tateki Kikuchi
MGI ID:	MGI:2684578
Synonyms:	cav-3-, cav3 -
Gene:	Cav3  Location: Chr6:112436466-112449833 bp, + strand  Genetic Position: Chr6, 52.26 cM, cytoband E1
Alliance:	Cav3tm1Ncnp page

Germline Transmission:	Earliest citation of germline transmission: J:66558
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced 0.8 kb of exon 2 through homologous recombination. Northern blot analysis demonstrated that no detectable transcript was expressed in skeletal muscle of homozygous mice, and western blot analysis confirmed that no protein was made from this allele. (J:66558)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Cav3 Mutation:	23 strains or lines available

Original:	J:66558 Hagiwara Y, et al., Caveolin-3 deficiency causes muscle degeneration in mice. Hum Mol Genet. 2000 Dec 12;9(20):3047-54
All:	15 reference(s)