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Slc27a4tm1Asta
Targeted Allele Detail
Summary
Symbol: Slc27a4tm1Asta
Name: solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1, Andreas Stahl
MGI ID: MGI:2684501
Gene: Slc27a4  Location: Chr2:29692646-29707534 bp, + strand  Genetic Position: Chr2, 20.64 cM, cytoband B
Alliance: Slc27a4tm1Asta page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86762
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA genomic fragment encompassing exons 1 and 2 was replaced with a cassette containing nls-lacZ and PGK-neo. The deleted sequence encoded the first 185 amino acids of the protein. Heterozygous mutant mice were shown to have approximately half as much protein as wild-type mice by Western blot analysis. (J:86762)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc27a4 Mutation:  36 strains or lines available
References
Original:  J:86762 Gimeno RE, et al., Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem. 2003 Dec 5;278(49):49512-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory