Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Krastm1Epa
Name:	Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Charles E Patek
MGI ID:	MGI:2684280
Synonyms:	K-rastmDelta4A
Gene:	Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Alliance:	Krastm1Epa page

Germline Transmission:	Earliest citation of germline transmission: J:86863
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4A was replaced with a neomycin resistance cassette. Absence of the 4A splice varient was confirmed by RT-PCR. (J:86863)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:	76 strains or lines available

Original:	J:86863 Plowman SJ, et al., While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable. Mol Cell Biol. 2003 Dec;23(24):9245-50
All:	5 reference(s)