Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tnfsf4tm1Shr
Name:	tumor necrosis factor (ligand) superfamily, member 4; targeted mutation 1, Arlene H Sharpe
MGI ID:	MGI:2683777
Synonyms:	Ox40L-/-, OX40Lo
Gene:	Tnfsf4  Location: Chr1:161223009-161245777 bp, + strand  Genetic Position: Chr1, 69.75 cM
Alliance:	Tnfsf4tm1Shr page

Germline Transmission:	Earliest citation of germline transmission: J:59203
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette inserted by homologous recombination replaced the exon encoding the entire extracellular domain and a portion of the 3' untranslated region. Protein was undetected by flow cytometric analysis of activated homozygous mutant dendritic cells. (J:59203)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf4 Mutation:	31 strains or lines available

Original:	J:59203 Chen AI, et al., Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity. 1999 Dec;11(6):689-98
All:	7 reference(s)