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Hoxb8tm1Omm
Targeted Allele Detail
Nomenclature
Symbol: Hoxb8tm1Omm
Name: homeobox B8; targeted mutation 1, Olga Medina-Martinez
MGI ID: MGI:2683089
Synonyms: Hoxb8hp
Gene: Hoxb8  Location: Chr11:96172731-96176141 bp, + strand  Genetic Position: Chr11, 59.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86684
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsMissense mutations were incorporated into the LFPWMR motif using a hit and run gene targeting technique. The codons encoding proline and tryptophan were mutated to encode valine and tyrosine, respectively (CCC(P) to GTA(V) and TGG(W) to TAC(Y)). Western blot analysis of fibroblast extracts the level of mutant protein in homozygous cells to be similar to that of normal protein in wild-type cells. (J:86684)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb8 Mutation:  4 strains or lines available
References
Original:  J:86684 Medina-Martinez O, et al., In vivo mutagenesis of the Hoxb8 hexapeptide domain leads to dominant homeotic transformations that mimic the loss-of-function mutations in genes of the Hoxb cluster. Dev Biol. 2003 Dec 1;264(1):77-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory