Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Esrratm1Vgi
Name:	estrogen related receptor, alpha; targeted mutation 1, Vincent Giguere
MGI ID:	MGI:2682818
Synonyms:	ERRalpha-
Gene:	Esrra  Location: Chr19:6888345-6899182 bp, - strand  Genetic Position: Chr19, 5.08 cM
Alliance:	Esrratm1Vgi page

Germline Transmission:	Earliest citation of germline transmission: J:86433
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2, which encodes the amino-terminal region and an essential component of its DNA-binding domain, was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted exon encoded the N-terminal region and a zinc finger domain. Northern blot analysis of renal RNA and Western blot analysis of intestinal protein indicated an absence of normal gene product in homozygous mutant mice. (J:86433)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esrra Mutation:	25 strains or lines available

Original:	J:86433 Luo J, et al., Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol Cell Biol. 2003 Nov;23(22):7947-56
All:	33 reference(s)