Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prnptm2.1Cwe
Name:	prion protein; targeted mutation 2.1, Charles Weissmann
MGI ID:	MGI:2682338
Synonyms:	Prnp lox1 (ZH II), Prnp- Zurich II
Gene:	Prnp  Location: Chr2:131751848-131780349 bp, + strand  Genetic Position: Chr2, 64.07 cM
Alliance:	Prnptm2.1Cwe page

Germline Transmission:	Earliest citation of germline transmission: J:67593
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 2.9 kb genomic fragment extending from within intron 2 through exon 3 was replaced with a single loxP site. The deleted region encompassed 0.26 kb of intron 2, the entire open reading frame of exon 3, the 3' non-coding region of exon 3, and 0.6 kb of adjacent 3' sequence. (J:67593)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:	150 strains or lines available

Original:	J:67593 Rossi D, et al., Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J. 2001 Feb 15;20(4):694-702
All:	4 reference(s)