Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol: Tgfbr1tm1.1Karl Name: transforming growth factor, beta receptor I; targeted mutation 1.1, Stefan Karlsson MGI ID: MGI:2680164 Synonyms: Alk5Flox, Alk5loxP, Tgfbr1f Gene: Tgfbr1  Location: Chr4:47353222-47414926 bp, + strand  Genetic Position: Chr4, 26.02 cM Alliance: Tgfbr1tm1.1Karl page

Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl Ptentm1Hwu/Ptentm1Hwu Tg(KRT14-cre/ERT)20Efu/0 mice develop anal squamous cell carcinoma Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:86262
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 3 was left flanked by single loxP sites after the removal of an upstream floxed neo cassette by the transient expression of cre recombinase in ES cells. (J:86262)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	102 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

List all tumor models in MMHCdb carrying Tgfbr1tm1.1Karl

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfbr1 Mutation:	36 strains or lines available

Original:	J:68770 Larsson J, et al., Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J. 2001 Apr 2;20(7):1663-73
All:	100 reference(s)