Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acvrl1tm1Spo
Name:	activin A receptor, type II-like 1; targeted mutation 1, S Paul Oh
MGI ID:	MGI:2680088
Synonyms:	Alk1lacZ
Gene:	Acvrl1  Location: Chr15:101026403-101043217 bp, + strand  Genetic Position: Chr15, 56.41 cM, cytoband F3
Alliance:	Acvrl1tm1Spo page

Germline Transmission:	Earliest citation of germline transmission: J:85877
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 to 8 were replaced with an IRES-lacZ/PKGneomycin cassette. The transmembrane domain coded by exon 5 is thus eliminated. (J:85877)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

34 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvrl1 Mutation:	26 strains or lines available

Original:	J:85877 Seki T, et al., Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ Res. 2003 Oct 3;93(7):682-9
All:	4 reference(s)