Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arxtm1Pgr
Name:	aristaless related homeobox; targeted mutation 1, Peter Gruss
MGI ID:	MGI:2679972
Gene:	Arx  Location: ChrX:92330113-92341963 bp, + strand  Genetic Position: ChrX, 41.05 cM
Alliance:	Arxtm1Pgr page

Germline Transmission:	Earliest citation of germline transmission: J:86206
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 and 2 were replaced with a cassette containing lacZ followed by floxed neo. The deleted sequence encodes 360 N-terminal residues which make up the octapeptide (Eh1 domain), alpha-helix 1, and approximately half of alpha-helix 2 homeodomain. Normal transcript was undetected by in situ hybridization of neural tube sections obtained from hemizygous fetuses. LacZ expression was detected. (J:86206)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	17 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arx Mutation:	20 strains or lines available

Original:	J:86206 Collombat P, et al., Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev. 2003 Oct 15;17(20):2591-603
All:	14 reference(s)