Fostm7Wag
Targeted Allele Detail
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| Symbol: |
Fostm7Wag |
| Name: |
FBJ osteosarcoma oncogene; targeted mutation 7, Erwin F Wagner |
| MGI ID: |
MGI:2679338 |
| Synonyms: |
c-fosf, Fostm1Pga |
| Gene: |
Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
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| Alliance: |
Fostm7Wag page
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Reduced tumor growth in Fostm7Wag/Fostm7Wag Tg(Cd4-cre)1Cwi/0 mice following carcinoma cell inoculation
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:85928
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: A loxP site was inserted in the first intron and a PGK neomycin cassette flanked by flp sites was inserted along with a second loxP site downstream of the polyadenylation signal. Still further downstream, a splice acceptor was placed just 5' to an EGFP gene insert. The PGK neo construct was deleted in vivo using flip recombinase transgenic mice.
(J:85928)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fos Mutation: |
42 strains or lines available
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| Original: |
J:85928 Fleischmann A, et al., Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J Neurosci. 2003 Oct 8;23(27):9116-22 |
| All: |
17 reference(s) |
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Analysis Tools
