Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Pde6gtm1Goff
Name:	phosphodiesterase 6G, cGMP-specific, rod, gamma; targeted mutation 1, Stephen P Goff
MGI ID:	MGI:2677504
Synonyms:	Pdegtm1
Gene:	Pde6g  Location: Chr11:120338433-120344326 bp, - strand  Genetic Position: Chr11, 84.14 cM
Alliance:	Pde6gtm1Goff page

Germline Transmission:	Earliest citation of germline transmission: J:33048
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced genomic sequences including the third exon. Western blot analysis on retinal homogenates derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:33048)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde6g Mutation:	11 strains or lines available

Original:	J:33048 Tsang SH, et al., Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase. Science. 1996 May 17;272(5264):1026-9
All:	13 reference(s)