Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hba-a1tm1Led
Name:	hemoglobin alpha, adult chain 1; targeted mutation 1, Philip Leder
MGI ID:	MGI:2677498
Synonyms:	alpha1-
Gene:	Hba-a1  Location: Chr11:32233672-32234486 bp, + strand  Genetic Position: Chr11, 18.86 cM
Alliance:	Hba-a1tm1Led page

Germline Transmission:	Earliest citation of germline transmission: J:41934
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a small 295 bp fragment in the second exon of the gene. Northern blot analysis on RNA derived from homozygous embryos demonstrated that a reduced amount of alpha-globin transcript was present in comparison to wild type. The authors propose that the remaining mRNA arose from the adjacent Hba-a2 gene. (J:41934)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hba-a1 Mutation:	3 strains or lines available

Original:	J:41934 Leder A, et al., Mouse zeta- and alpha-globin genes: Embryonic survival, alpha-thalassemia, and genetic background effects. Blood. 1997 AUG 1;90(3):1275-1282
All:	2 reference(s)