Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sirt1tm2.1Fwa
Name:	sirtuin 1; targeted mutation 2.1, Frederick W Alt
MGI ID:	MGI:2677369
Synonyms:	SIRT1-, SIRT1delta, SIRT1null, SIRT null
Gene:	Sirt1  Location: Chr10:63154784-63174814 bp, - strand  Genetic Position: Chr10, 32.57 cM
Alliance:	Sirt1tm2.1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:85542
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A single loxP site remained in place of exons 5, 6, and 7 after the floxed neo cassette inserted by homologous recombination was excised via in vitro cre-mediated recombination. Protein was undetected in homozygous mutant MEFs by Western blot analysis using an antibody specific for the N-terminal. (J:85542)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt1 Mutation:	78 strains or lines available

Original:	J:85542 Cheng HL, et al., Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9
All:	30 reference(s)