Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thrbtm4Few
Name:	thyroid hormone receptor beta; targeted mutation 4, Frederic E Wondisford
MGI ID:	MGI:2676951
Synonyms:	TR-Beta-, TRbetaKO
Gene:	Thrb  Location: Chr14:4431611-4809435 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A3
Alliance:	Thrbtm4Few page

Germline Transmission:	Earliest citation of germline transmission: J:85158
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was replaced with a self-excising PGK-neo cassette. The deletion of exon 3 putatively results in an aberrant open reading frame caused by the fusion of exons 2 and 4. Using a C-terminal mAb, protein was undetected by Western blot analysis of homozygous mutant mice. (J:85158)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thrb Mutation:	39 strains or lines available

Original:	J:85158 Shibusawa N, et al., Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest. 2003 Aug;112(4):588-97
All:	3 reference(s)