Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fbxo32tm1Glas
Name:	F-box protein 32; targeted mutation 1, David J Glass
MGI ID:	MGI:2676047
Synonyms:	MAFbx -
Gene:	Fbxo32  Location: Chr15:58039275-58078288 bp, - strand  Genetic Position: Chr15, 24.43 cM, cytoband D2
Alliance:	Fbxo32tm1Glas page

Germline Transmission:	Earliest citation of germline transmission: J:77660
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An in-frame lacZ gene and neomycin selection cassette replaced approximately 35 kb of gene sequences, including exons 1-7 and most of exon 8. Northern blot analysis on RNA derived from muscle of homozygous mice confirmed that no wild-type transcript is expressed from this allele. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter. (J:77660)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbxo32 Mutation:	17 strains or lines available

Original:	J:77660 Bodine SC, et al., Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001 Nov 23;294(5547):1704-8
All:	8 reference(s)