Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ltatm1Tab
Name:	lymphotoxin A; targeted mutation 1, Theresa A Banks
MGI ID:	MGI:1860957
Synonyms:	LT-alpha-, LTalpha-
Gene:	Lta  Location: Chr17:35422141-35424327 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance:	Ltatm1Tab page

Germline Transmission:	Earliest citation of germline transmission: J:28061
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a portion of exon 2, all of exon 3, and a portion of exon 4 of the gene. Southern blots confirmed absence of both wild-type alleles in homozygous mutant mice. RT-PCR of Con A-stimulated splenocytes from homozygous mutant mice showed no detectable mRNA for the targeted gene. (J:28061)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lta Mutation:	17 strains or lines available

Original:	J:28061 Banks TA, et al., Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol. 1995 Aug 15;155(4):1685-93
All:	15 reference(s)