Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Akt1tm1Hem Name: thymoma viral proto-oncogene 1; targeted mutation 1, Brian A Hemmings MGI ID: MGI:2675202 Synonyms: Akt1-, Pkbalpha- Gene: Akt1  Location: Chr12:112620260-112641266 bp, - strand  Genetic Position: Chr12, 61.2 cM, cytoband F1-F2 Alliance: Akt1tm1Hem page

Structural abnormalities of E14 Akt1tm1Hem/Akt1tm1Hem mouse placenta Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:85181
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A cassette containing lacZ and neo was inserted into exon 1 at the start codon via homologous recombination. The insertion deleted the coding region of exon 1 which encodes 15 N-terminal residues. Endogenous protein was undetected by Western blot analysis of homozygous mutant heart tissue. (J:85181)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt1 Mutation:	34 strains or lines available

Original:	J:85181 Yang ZZ, et al., Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem. 2003 Aug 22;278(34):32124-31
All:	27 reference(s)