Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mdm2tm1Mep
Name:	transformed mouse 3T3 cell double minute 2; targeted mutation 1, Mary Ellen Perry
MGI ID:	MGI:2673927
Synonyms:	mdm2puro
Gene:	Mdm2  Location: Chr10:117524780-117546663 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Alliance:	Mdm2tm1Mep page

Germline Transmission:	Earliest citation of germline transmission: J:81065
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: Exons 7, 8, and 9 were flanked by a floxed puromycin selection cassette in intron 6 and a single loxP site in intron 9. Northern and Western blot analyses, as well as phenotypic analysis, indicated that this allele is hypomorphic. Further breeding of mice carrying this allele with cre transgenic mice led to the generation of Mdm2tm1.1Mep and Mdm2tm1.2Mep. (J:81065)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:	54 strains or lines available

Original:	J:81065 Mendrysa SM, et al., mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation. Mol Cell Biol. 2003 Jan;23(2):462-72
All:	7 reference(s)