Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nr1d1tm1Schb
Name:	nuclear receptor subfamily 1, group D, member 1; targeted mutation 1, Ueli Schibler
MGI ID:	MGI:2671157
Synonyms:	Reverba, Rev-erbalpha -
Gene:	Nr1d1  Location: Chr11:98658758-98666159 bp, - strand  Genetic Position: Chr11, 62.66 cM
Alliance:	Nr1d1tm1Schb page

Germline Transmission:	Earliest citation of germline transmission: J:78197
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing part of exon 2, exons 3 and 4 and part of exon 5 was replaced with an in-frame lacZ gene and a neomycin selection cassette. Northern blot analysis demonstrated that no detectable transcript is expressed from this allele, and Western blot analysis confirmed that no detectable protein is made from this allele. (J:78197)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	104038 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr1d1 Mutation:	40 strains or lines available

Original:	J:78197 Preitner N, et al., The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002 Jul 26;110(2):251-60
All:	23 reference(s)