Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Ro60tm1Woln Name: Ro60, Y RNA binding protein; targeted mutation 1, Sandra L Wolin MGI ID: MGI:2670227 Synonyms: Ro-/- Gene: Ro60  Location: Chr1:143626528-143652794 bp, - strand  Genetic Position: Chr1, 62.54 cM Alliance: Ro60tm1Woln page

Glomerulonephritis in Ro60tm1Woln/Ro60tm1Woln mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:84627
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetectable by Western blot analysis of homozygous mutant brain extracts. (J:84627)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ro60 Mutation:	39 strains or lines available

Original:	J:84627 Xue D, et al., A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7503-8
All:	2 reference(s)